Ibudilast - MediciNova

Drug Profile

Ibudilast - MediciNova

Alternative Names: AV-411; Eyevinal; Ibinal; KC-404; Ketas; MN-166; Pinatos

Latest Information Update: 08 Oct 2018

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At a glance

  • Originator Kyorin Pharmaceutical
  • Developer Banyu; Kyorin Pharmaceutical; MediciNova; National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; Senju Pharmaceutical; University of California at Los Angeles; University of Colorado at Boulder; University of New South Wales
  • Class 2 ring heterocyclic compounds; Anti-inflammatories; Antiasthmatics; Antihyperglycaemics; Antiplatelets; Non-opioid analgesics; Nootropics; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action Astrocyte inhibitors; Cytokine modulators; Glial cell modulators; Leukotriene receptor antagonists; Macrophage migration inhibitory factor inhibitors; Nitric oxide synthase inhibitors; Phosphodiesterase 10A inhibitors; Phosphodiesterase 11A inhibitors; Toll-like receptor 4 antagonists; Type 3 cyclic nucleotide phosphodiesterase inhibitors; Type 4 cyclic nucleotide phosphodiesterase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma; Amyotrophic lateral sclerosis; Globoid cell leukodystrophy
  • New Molecular Entity Yes
  • Available For Licensing Yes - Alcoholism; Drug abuse; Neurological disorders; Opioid abuse

Highest Development Phases

  • Marketed Allergic conjunctivitis; Asthma; Cerebrovascular disorders
  • Phase II Alcoholism; Amyotrophic lateral sclerosis; Drug abuse; Multiple sclerosis; Opioid abuse
  • Preclinical Glioblastoma; Globoid cell leukodystrophy
  • Suspended Neuropathic pain
  • No development reported Brain injuries; Headache
  • Discontinued Diabetic neuropathies; Diabetic retinopathy

Most Recent Events

  • 04 Oct 2018 Ibudilast - MediciNova receives Orphan Drug status for Glioblastoma (Adjunctive treatment) in USA
  • 25 Sep 2018 MediciNova receives positive feedback from US FDA regarding planned phase III trial of ibudilast in Amyotrophic lateral sclerosis
  • 25 Sep 2018 MediciNova plans a phase III trial for Amyotrophic lateral sclerosis in USA
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