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Romidepsin - Celgene Corporation

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Drug Profile

Romidepsin - Celgene Corporation

Alternative Names: Depsipeptide; FK 228; FR 901228; Istodax; NSC 630176; NSC 630176D; RMD

Latest Information Update: 20 Apr 2025

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At a glance

  • Originator Astellas Pharma
  • Developer Canadian Cancer Trials Group; Celgene Corporation; Columbia University; Lymphoma Academic Research Organisation; University of Birmingham; University of California at San Francisco; University of Kansas Medical Center; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Cytostatic antibiotics; Depsipeptides; Small molecules
  • Mechanism of Action Histone deacetylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Peripheral T-cell lymphoma; Cutaneous T-cell lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Cutaneous T-cell lymphoma
  • Registered Peripheral T-cell lymphoma
  • Phase I/II Lymphoid leukaemia; Multiple myeloma; T-cell leukaemia; T-cell lymphoma; Triple negative breast cancer
  • No development reported Diffuse large B cell lymphoma; Haematological malignancies
  • Discontinued Pancreatic cancer; Prostate cancer; Renal cell carcinoma

Most Recent Events

  • 31 Jan 2024 Fox Chase Cancer Center completes a phase I trial for Cutaneous T-cell lymphoma (Combination therapy, Metastatic disease, Late-stage disease, Second-line therapy or greater) in the US (IV) (NCT02616965)
  • 14 Dec 2023 Seagen has been acquired by Pfizer
  • 01 Nov 2023 Celgene completes a phase I/II trial in Multiple myeloma (Combination therapy, Second-line or greater) in the USA (IV) (NCT01755975)

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