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Talotrexin

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Drug Profile

Talotrexin

Alternative Names: PT-523; Talvesta

Latest Information Update: 24 Oct 2021

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At a glance

  • Originator Ash Stevens; Dana-Farber Cancer Institute
  • Developer Hana Biosciences
  • Class Antineoplastics; Benzoic acids
  • Mechanism of Action Tetrahydrofolate dehydrogenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Precursor cell lymphoblastic leukaemia-lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Breast cancer; Colorectal cancer; Head and neck cancer; Lung cancer; Non-small cell lung cancer; Precursor cell lymphoblastic leukaemia-lymphoma; Rheumatoid arthritis; Solid tumours

Most Recent Events

  • 09 Oct 2008 Discontinued - Phase-I for Solid tumours in USA (IV)
  • 09 Oct 2008 Discontinued - Phase-II for Acute lymphoblastic leukaemia in USA (IV)
  • 18 Dec 2006 Phase-II clinical trials in Acute lymphoblastic leukaemia in USA (IV-infusion)

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