Afamelanotide - Clinuvel Pharmaceuticals
Alternative Names: [Nle4,DPhe7]-alpha-MSH; Afamelanotide acetate; CUV-1647; EPT-1647; Melanotan I; Melanotan™; MT I; PRENUMBRA; Scenesse; Scenesse® EnfanceLatest Information Update: 06 Oct 2025
At a glance
- Originator University of Arizona
- Developer Clinuvel Pharmaceuticals; Winhealth Pharma
- Class Antiacnes; Antineoplastics; Antipyretics; Melanocyte-stimulating hormones; Peptides; Skin disorder therapies; Vascular disorder therapies
- Mechanism of Action Melanocortin type 1 receptor agonists
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Marketed Erythropoietic protoporphyria
- Phase III Polymorphus light eruptions; Vitiligo
- Phase II Hepatic-porphyria; Ischaemic stroke; Pemphigus; Xeroderma pigmentosum
- Preclinical Parkinson's disease
- Suspended Urticaria
- Discontinued Acne vulgaris; Actinic keratosis; Photodamage; Squamous cell cancer
Most Recent Events
- 01 Oct 2025 Clinuvel Pharmaceuticals plans a preclinical program for new formulations
- 19 Sep 2025 Efficacy data form phase-III clinical trial in Vitiligo released by Clinuvel Pharmaceuticals
- 26 Mar 2025 Efficacy and adverse events data from a phase II trial in Ischaemic stroke released by Clinuvel Pharmaceuticals