Siltuximab - Janssen Biotech

Drug Profile

Siltuximab - Janssen Biotech

Alternative Names: Anti-interleukin-6 monoclonal antibody - Centocor; cCLB8; Chimeric anti-interleukin-6 monoclonal antibody - Centocor; CNTO-328; Sylvant

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Centocor
  • Developer Centocor; Janssen Biotech; Memorial Sloan-Kettering Cancer Center
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Interleukin 6 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Giant lymph node hyperplasia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Giant lymph node hyperplasia
  • Phase II Multiple myeloma
  • No development reported Paraproteinaemia
  • Discontinued Myelodysplastic syndromes; Non-Hodgkin's lymphoma; Prostate cancer; Renal cell carcinoma

Most Recent Events

  • 18 Jul 2018 Janssen Sciences Ireland enters into an agreement with EUSA Pharma to licenses siltuximab, worldwide
  • 18 Jul 2018 Registered for Giant lymph node hyperplasia in South Korea (IV) before July 2018
  • 24 Jun 2018 Biomarkers information updated
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