Drug Profile

Cetuximab - Eli Lilly and Company

Alternative Names: Anti-EGFR monoclonal antibody 225; C 225; ch 225; Erbitux; IMC-C225; LY-2939777

Latest Information Update: 06 Aug 2026

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At a glance

Originator University of California
Developer Array BioPharma; Bristol-Myers Squibb; Celldex Therapeutics Inc; Centre Jean Perrin; Eli Lilly; Eli Lilly and Company; Fudan University; Merck KGaA; National Cancer Institute (USA); New York University School of Medicine; Novartis; Pfizer; Pierre Fabre; Radiation Therapy Oncology Group; Roche; UNICANCER; University of Michigan Comprehensive Cancer Center
Class Antineoplastics; Immunotherapies; Monoclonal antibodies
Mechanism of Action Angiogenesis inhibitors; Antibody-dependent cell cytotoxicity; ErbB receptor antagonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Squamous cell cancer
New Molecular Entity Yes

Marketed Colorectal cancer; Head and neck cancer
Phase III Non-small cell lung cancer
Phase II Bladder cancer; Breast cancer; Gastric cancer; Malignant-mesothelioma; Rectal cancer; Squamous cell cancer
Phase I/II Adenoid cystic carcinoma; Solid tumours
Phase Unknown Oesophageal cancer
No development reported Pancreatic cancer; Prostate cancer

22 Jul 2026 ALX Oncology, Eli Lilly and Company and Merck terminates a phase II trial in Colorectal cancer (Combination therapy, Metastatic disease, Second-line therapy or greater) in USA due to safety concerns (IV) (NCT05167409)
14 Jul 2026 European Commission approves update to cetuximab EU label in Colorectal Cancer (Metastatic disease; first line therapy)
02 Jun 2026 Updated efficacy and adverse events data from phase III trial in Colorectal cancer presented at the 62nd Annual Meeting of the American Society of Clinical Oncology (ASCO-2026)

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