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Cetuximab - Eli Lilly and Company

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Drug Profile

Cetuximab - Eli Lilly and Company

Alternative Names: Anti-EGFR monoclonal antibody 225; C 225; ch 225; Erbitux; IMC-C225; LY-2939777

Latest Information Update: 22 Nov 2024

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At a glance

  • Originator University of California
  • Developer Array BioPharma; Bristol-Myers Squibb; Celldex Therapeutics Inc; Centre Jean Perrin; Eli Lilly; Eli Lilly and Company; Fudan University; Merck KGaA; National Cancer Institute (USA); New York University School of Medicine; Novartis; Pfizer; Pierre Fabre; Radiation Therapy Oncology Group; Roche; UNICANCER; University of Michigan Comprehensive Cancer Center
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Angiogenesis inhibitors; Antibody-dependent cell cytotoxicity; Epidermal growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Squamous cell cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Colorectal cancer; Head and neck cancer
  • Phase III Non-small cell lung cancer
  • Phase II Bladder cancer; Breast cancer; Gastric cancer; Malignant-mesothelioma; Rectal cancer; Squamous cell cancer
  • Phase I/II Adenoid cystic carcinoma; Solid tumours
  • Phase Unknown Oesophageal cancer
  • No development reported Pancreatic cancer; Prostate cancer

Most Recent Events

  • 22 Nov 2024 Cetuximab is still in phase III development for Colorectal cancer (Combination therapy, In adolescents, In the elderly, Late-stage disease, Metastatic disease, Second-line therapy or greater, In adults) in Ukraine, Argentina, Australia, Germany, India, South Africa, Mexico, China, Italy, New Zealand, Bulgaria, Japan, Canada, Spain, Taiwan, Norway, Brazil, Sweden, France, Czech Republic, Slovakia, Finland, United Kingdom, South Korea, Russia, Netherlands, Denmark, Poland and Belgium (IV) (NCT04607421) (EudraCT2020-001288-99)
  • 19 Nov 2024 Discontinued - Phase-III for Non-small cell lung cancer (First-line therapy, Combination therapy, Late-stage disease, Inoperable/Unresectable, Newly diagnosed) in Canada (IV)
  • 19 Nov 2024 Discontinued - Phase-III for Non-small cell lung cancer (Newly diagnosed, Inoperable/Unresectable, Late-stage disease, Combination therapy, First-line therapy) in USA (IV)

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