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Tamibarotene - Nippon Shinyaku/Syros Pharmaceuticals/Toko Pharmaceutical

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Drug Profile

Tamibarotene - Nippon Shinyaku/Syros Pharmaceuticals/Toko Pharmaceutical

Alternative Names: AM-80; Amnoid; Amnolake; INNO-507; NSC-608000; OMS0728; OP-01-Nippon Shinyaku/Syros Pharmaceuticals/Toko Pharmaceutical; Oral RARa agonist - Syros Pharmaceuticals; Retinobenzoic acid; RR-110; SY-1425; Tamibaro; Tamibarotene; TM-411; TOS-80T; Z-208

Latest Information Update: 25 Nov 2024

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At a glance

  • Originator Shionogi
  • Developer Childrens Hospital Los Angeles; CytRx Corporation; Gyre Therapeutics; Nagoya University; Nippon Shinyaku; Ohara Pharmaceutical; Syros Pharmaceuticals; TMRC Co. Ltd; Toko Pharmaceutical Industrial; Zeria
  • Class Antineoplastics; Benzoates; Retinoids; Small molecules; Tetrahydronaphthalenes
  • Mechanism of Action Retinoic acid receptor alpha agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute promyelocytic leukaemia; Myelodysplastic syndromes; Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acute promyelocytic leukaemia
  • Phase II Acute myeloid leukaemia; Myelodysplastic syndromes
  • Phase I/II Pancreatic cancer
  • No development reported Neutropenia; Solid tumours
  • Discontinued Crohn's disease; HER2 positive breast cancer; Liver cancer; Non-small cell lung cancer; Psoriasis; Rheumatoid arthritis

Most Recent Events

  • 14 Nov 2024 Discontinued - Phase-III SELECT-MDS-1 trial for Myelodysplastic syndromes (First-line therapy, Combination therapy) in USA, Austria, Canada, Belgium, Spain, France, Germany, Czech Republic, Hungary, Poland, Israel, Italy and the United Kingdom due to unsatisfactory results before November 2024 (NCT04797780)
  • 14 Nov 2024 Efficacy and adverse events data from a phase III SELECT-MDS-1 trial in Myelodysplastic syndrome released by Syros Pharmaceuticals
  • 12 Aug 2024 Adverse events and efficacy data from a phase II for Acute myeloid leukaemia released by Syros Pharmaceuticals

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