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Drug Profile


Alternative Names: SKF 106615

Latest Information Update: 31 Mar 2022

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At a glance

  • Originator AnorMED; University of Texas M. D. Anderson Cancer Center
  • Developer Callisto Pharmaceuticals
  • Class Anti-inflammatories; Antirheumatics; Small molecules; Spiro compounds
  • Mechanism of Action Angiogenesis inhibitors; Apoptosis stimulants; Immunomodulators; Interleukin 1 modulators; Interleukin-6 modulators; Macrophage modulators; Osteoclast modulators; Proto oncogene protein c-akt inhibitors; STAT3 transcription factor inhibitors; Tumour necrosis factor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple myeloma; Carcinoid tumour
  • New Molecular Entity No
  • Available For Licensing Yes - Rheumatoid arthritis

Highest Development Phases

  • Discontinued Carcinoid tumour; Inflammation; Multiple myeloma; Osteoporosis; Rheumatoid arthritis; Solid tumours

Most Recent Events

  • 28 Jan 2009 Preclinical trials in Rheumatoid arthritis in USA (PO)
  • 03 Jun 2008 Efficacy and safety data from a phase II trial in Carcinoid tumour presented at the 44th Annual Meeting of the American Society of Clinical Oncology (ASCO-2008)
  • 16 May 2008 Interim efficacy data from a Phase-II trial in Carcinoid tumour released by Callisto Pharmaceuticals
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