Retigabine

Drug Profile

Retigabine

Alternative Names: ADD-230001; AW21-360; D-20443; D-20443 dihydrochloride; D-23129; Ezogabine; Ezogabine-XR; GKE 841; GW-582892X; Potiga; Trobalt; WAY-143841

Latest Information Update: 25 Oct 2017

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At a glance

  • Originator Meda
  • Developer GlaxoSmithKline; Harvard University; Massachusetts General Hospital; The ALS Association; Valeant Pharmaceuticals International
  • Class Antiepileptic drugs; Carbamates; Fluorobenzenes; Phenylenediamines; Small molecules
  • Mechanism of Action GABA A receptor agonists; KCNQ potassium channel agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Partial epilepsies
  • Phase III Lennox-Gastaut syndrome
  • Phase II Amyotrophic lateral sclerosis
  • Discontinued Postherpetic neuralgia

Most Recent Events

  • 13 Sep 2017 Phase-III clinical trials in Partial epilepsies (Adjunctive treatment) in Malaysia (PO) (NCT01777139)
  • 13 Sep 2017 GlaxoSmithKline completes a phase III trial in Partial epilepsies (adjunctive treatment) in Malaysia, South Korea, Thailand (PO) (NCT01777139)
  • 13 Sep 2017 GlaxoSmithKline completes a phase III extension trial in Partial seizures (Adjunctive treatment) in Russia, Thailand, Ukraine and European Union (PO) (NCT01336621) (EudraCT2010-022777-34)
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