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Drug Profile


Alternative Names: DDP 733; MKC 733

Latest Information Update: 23 Jun 2015

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At a glance

  • Originator Mitsubishi Chemical
  • Developer Dynogen Pharmaceuticals; Edusa Pharmaceuticals; Mitsubishi Chemical
  • Class Gastrokinetics; Irritable bowel syndrome therapies; Laxatives; Quinuclidines; Small molecules
  • Mechanism of Action Serotonin 5-HT3 receptor partial agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Constipation; Dyspepsia; Gastro-oesophageal reflux; Irritable bowel syndrome; Reflux oesophagitis

Most Recent Events

  • 12 Jul 2010 Phase-II clinical trials in Gastro-oesophageal reflux in USA (PO)
  • 22 May 2008 Final safety and efficacy data from a phase IIa (IBS-c) trial in Irritable bowel syndrome presented at the Digestive Disease Week 2008 (DDW-2008) ,
  • 09 Nov 2007 Phase-II clinical trials in Irritable bowel syndrome in USA (PO)
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