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Rifaximin - Alfasigma

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Drug Profile

Rifaximin - Alfasigma

Alternative Names: Dermodis; EIR formulation of rifaximin - Salix Pharmaceuticals; Flonorm; L-105; Lumenax; Normix; RedActive®; Rifacol; Rifaxidin®; Rifaximin soluble solid dispersion tablet; Rifaximin SSD; Rifaximin-a 550mg; rifaximin-alpha; Rifxima; SLX-G1043; SLX-G1063; SLX-L1042; SLX-L1044; Spiraxin; Targaxan 550; Tixtar; Xifaxan; Xifaxan 550mg; XIFAXAN550; Xifaxanta; Zaxine

Latest Information Update: 03 Feb 2026

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At a glance

  • Originator Alfa Wassermann SpA
  • Developer Alfa Wassermann SpA; Alfasigma; ASKA Pharmaceutical; Bausch Health Companies; Lupin; Norgine; Salix Pharmaceuticals; University of Washington; Yokohama City University
  • Class Anti-infectives; Anti-inflammatories; Antianaemics; Antibacterials; Antidiarrhoeals; Hepatoprotectants; Irritable bowel syndrome therapies; Rifamycins; Skin disorder therapies; Small molecules
  • Mechanism of Action DNA-directed RNA polymerase inhibitors; Transcription factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hepatic encephalopathy; Sickle cell anaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Diverticulitis; Hepatic encephalopathy; Hyperammonaemia; Intestinal infections; Irritable bowel syndrome; Skin and soft tissue infections; Traveller's diarrhoea
  • Phase III Crohn's disease; Liver disorders
  • Phase II Intestinal obstruction; Rosacea; Sickle cell anaemia
  • Phase Unknown COVID 2019 infections
  • No development reported Unspecified
  • Discontinued Bacterial vaginosis; Clostridium difficile infections; Pouchitis; Shigella infections

Most Recent Events

  • 23 Jan 2026 Adverse event data from the phase III RED-C-3132 trial in Hepatic encephalopathy released by Bausch health companies
  • 25 May 2024 Salix Pharmaceuticals completes a phase I pharmacokinetic trial in healthy adults in Hungary and USA (CTIS2023-505434-98-00)
  • 25 Apr 2024 Bausch Health Companies plans to submit NDA for Liver disorders (prevention of complications of decompensated cirrhosis) in 2026

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