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Samarium 153 lexidronam

Drug Profile

Samarium 153 lexidronam

Alternative Names: 153SM samarium ethylenediaminetetramethylene phosphonic acid; CYT 424; Quadramet; Samarium 153 EDTMP; Samarium SM 153 lexidronam pentasodium; Sm 153 EDTMP

Latest Information Update: 15 May 2018

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At a glance

  • Originator Dow Chemical
  • Developer CIS bio international; EUSA Pharma; Lantheus Medical Imaging; Superna Life Sciences
  • Class Analgesics; Inorganic chemicals; Radiopharmaceuticals
  • Mechanism of Action Ionising radiation emitters; Reactive oxygen species stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Marketed Pain
  • Discontinued Bone metastases; Breast cancer; Multiple myeloma; Osteosarcoma; Prostate cancer; Rheumatoid arthritis

Most Recent Events

  • 02 Apr 2015 Samarium 153 lexidronam is still in phase I/II trials for Multiple myeloma (Combination therapy, Recurrent) in the USA
  • 02 Apr 2015 Samarium 153 lexidronam is still in phase II trials for Prostate cancer in the USA
  • 01 Nov 2014 M.D. Anderson Cancer Center in collaboration with Cytogen complete a phase II trial in Breast Cancer in USA (NCT00429507)
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