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Asimadoline - Tioga Pharmaceuticals

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Drug Profile

Asimadoline - Tioga Pharmaceuticals

Alternative Names: EMD-61753; EMR 63 320; ONO-3951; TP-0052

Latest Information Update: 03 Jul 2025

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At a glance

  • Originator Merck KGaA
  • Developer Merck KGaA; Ono Pharmaceutical; Tioga Pharmaceuticals
  • Class Acetamides; Opioid analgesics; Pyrrolidines; Small molecules
  • Mechanism of Action Opioid kappa receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Pruritus; Vasomotor symptoms
  • Discontinued Irritable bowel syndrome; Pain; Postoperative ileus

Most Recent Events

  • 01 Jul 2025 Phase-II clinical trials in Vasomotor symptoms (In adults) in USA (PO) (NCT07042516)
  • 09 Apr 2021 Asimadoline is still in phase II trials for Pruritus (In adults, In the elderly) in USA (PO) (Tioga Pharmaceuticals pipeline, April 2021)
  • 04 Dec 2017 Safety and efficacy data from a phase II clinical trial in Pruritus released by Tioga Pharmaceuticals

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