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Eculizumab - Alexion AstraZencea Rare Disease

Drug Profile

Eculizumab - Alexion AstraZencea Rare Disease

Alternative Names: 5G1-1; 5G1.1; Anti-C5 monoclonal antibody 5G1-1; h5G1.1; Monoclonal antibody 5G1-1; Soliris

Latest Information Update: 08 Dec 2023

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At a glance

  • Originator Alexion Pharmaceuticals
  • Developer Alexion AstraZeneca Rare Disease; Alexion Pharmaceuticals; Brigham and Womens Hospital; Handok Inc
  • Class Anti-inflammatories; Antiallergics; Antianaemics; Antiasthmatics; Antihypertensives; Antipsoriatics; Antirheumatics; Eye disorder therapies; Monoclonal antibodies; Neuroprotectants; Skin disorder therapies; Urologics
  • Mechanism of Action Complement C5 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Paroxysmal nocturnal haemoglobinuria; Delayed graft function; Neuromyelitis optica; Transplant rejection; Haemolytic uraemic syndrome; Myasthenia gravis; Dermatomyositis; Membranous glomerulonephritis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Haemolytic uraemic syndrome; Myasthenia gravis; Neuromyelitis optica; Paroxysmal nocturnal haemoglobinuria
  • Phase III Delayed graft function; Guillain-Barre syndrome
  • Phase II Preeclampsia; Renal transplant rejection
  • Clinical Phase Unknown COVID-19 pneumonia; SARS-CoV-2 acute respiratory disease
  • No development reported Antiphospholipid syndrome; Heart transplant rejection
  • Discontinued Adult respiratory distress syndrome; Age-related macular degeneration; Allergic asthma; Autoimmune haemolytic anaemia; Bullous pemphigoid; Dermatomyositis; Glomerulonephritis; Idiopathic thrombocytopenic purpura; Lupus nephritis; Membranous glomerulonephritis; Motor neuron disease; Psoriasis; Rheumatoid arthritis; Systemic lupus erythematosus

Most Recent Events

  • 29 Nov 2023 Cedars-Sinai Medical Center in collaboration with Alexion Pharmaceuticals terminates a phase II trial in Preeclampsia (In adolescents, In the elderly, In adults) in USA (IV) due to PI moved institutions (NCT04725812)
  • 06 Nov 2023 Alexion Pharmaceuticals completes phase III trial in Myasthenia gravis (In children, In adolescents, Treatment-experienced) in Japan, USA, Germany, Netherlands (IV) (NCT03759366) (EudraCT-2016-001384-37)
  • 18 Oct 2023 Registered for Neuromyelitis optica (In adults) in China (IV)
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