Eculizumab - Alexion Pharmaceuticals

Drug Profile

Eculizumab - Alexion Pharmaceuticals

Alternative Names: 5G1-1; 5G1.1; Anti-C5 monoclonal antibody 5G1-1; h5G1.1; Monoclonal antibody 5G1-1; Soliris

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Alexion Pharmaceuticals
  • Developer Alexion Pharmaceuticals; Brigham and Womens Hospital; Chiba University; Handok Inc
  • Class Anti-inflammatories; Antiallergics; Antianaemics; Antiasthmatics; Antirheumatics; Eye disorder therapies; Immunotherapies; Monoclonal antibodies; Neuroprotectants; Skin disorder therapies
  • Mechanism of Action Complement C5 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Paroxysmal nocturnal haemoglobinuria; Delayed graft function; Neuromyelitis optica; Transplant rejection; Haemolytic uraemic syndrome; Myasthenia gravis; Dermatomyositis; Membranous glomerulonephritis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Haemolytic uraemic syndrome; Myasthenia gravis; Paroxysmal nocturnal haemoglobinuria
  • Phase III Delayed graft function; Neuromyelitis optica
  • Phase II Guillain-Barre syndrome; Renal transplant rejection
  • No development reported Antiphospholipid syndrome; Heart transplant rejection
  • Discontinued Adult respiratory distress syndrome; Age-related macular degeneration; Allergic asthma; Autoimmune haemolytic anaemia; Bullous pemphigoid; Dermatomyositis; Glomerulonephritis; Idiopathic thrombocytopenic purpura; Lupus nephritis; Membranous glomerulonephritis; Motor neuron disease; Psoriasis; Rheumatoid arthritis; Systemic lupus erythematosus

Most Recent Events

  • 24 Sep 2018 Alexion Pharmaceuticals announces intention to file regulatory applications for Neuromyelitis Optica in USA, European Union and Japan
  • 24 Sep 2018 Safety and efficacy data from the phase III PREVENT trial in Neuromyelitis optica released by Alexion Pharmaceuticals
  • 01 Jul 2018 Alexion completes the phase-III PREVENT trial in Neuromyelitis optica in USA, Australia, Canada, Croatia, Colombia, Czech Republic, Denmark, France, Germany, Hong Kong, Italy, Japan, Malaysia, South Korea, Russia, Singapore, Spain, Taiwan, Turkey, United Kingdom, Argentina, Austria and Thailand (IV) (NCT01892345)
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