Imatinib - Novartis

Drug Profile

Imatinib - Novartis

Alternative Names: CGP 57148; CGP 57148B; CTI 571; Gleevec; Glivec; Imatinib mesilate; Imatinib mesylate; QTI 571; Ruvise; STI 571

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Novartis
  • Developer Dana-Farber Cancer Institute; Novartis; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Antivirals; Benzamides; Piperazines; Pyridines; Pyrimidines; Small molecules
  • Mechanism of Action Bcr-abl tyrosine kinase inhibitors; Platelet-derived growth factor inhibitors; Platelet-derived growth factor receptor antagonists; Proto oncogene protein c-kit inhibitors; Signal transduction pathway inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastrointestinal stromal tumours; Chronic myeloid leukaemia; Precursor cell lymphoblastic leukaemia-lymphoma; Dermatofibrosarcoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Chronic myeloid leukaemia; Dermatofibrosarcoma; Gastrointestinal stromal tumours; Hypereosinophilic syndrome; Myelodysplastic syndromes; Precursor cell lymphoblastic leukaemia-lymphoma; Systemic mastocytosis
  • Phase II Acute myeloid leukaemia; Fibroma; Non-Hodgkin's lymphoma; Prostate cancer
  • No development reported Malignant melanoma; Mesothelioma
  • Discontinued Diffuse scleroderma; Glioblastoma; Non-small cell lung cancer; Polycythaemia vera; Pulmonary arterial hypertension; Sarcoma; Small cell lung cancer; Systemic scleroderma

Most Recent Events

  • 04 Nov 2017 No recent reports of development identified for phase-I development in Mesothelioma(Inoperable/Unresectable, Metastatic disease) in USA (PO)
  • 12 Jul 2017 Novartis completes a phase III trial in Gastrointestinal stromal tumours (Adjuvant therapy) in Germany, Denmark, United Kingdom, Spain, Italy, Australia and France (PO) (NCT00103168) (EudraCT2004-001810-16)
  • 02 Jun 2017 Adverse events and efficacy data from the phase-II PERSIST-5 trial in Gastrointestinal stromal tumours (Adjuvant therapy) presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
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