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Nelarabine - GlaxoSmithKline

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Drug Profile

Nelarabine - GlaxoSmithKline

Alternative Names: 506U; 506U78; Arranon; Atriance; C 506; Compound 506; GW 506U; GW 506U78; Nelzarabine

Latest Information Update: 02 May 2025

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At a glance

  • Originator GlaxoSmithKline
  • Developer National Cancer Institute (USA); Novartis
  • Class Antineoplastics; Arabinonucleosides; Small molecules
  • Mechanism of Action DNA inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Precursor cell lymphoblastic leukaemia-lymphoma; T-cell lymphoma; Chronic lymphocytic leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Precursor cell lymphoblastic leukaemia-lymphoma; T-cell lymphoma
  • Discontinued Chronic lymphocytic leukaemia

Most Recent Events

  • 31 Mar 2025 National Cancer Institute completes a phase III trial in T-cell lymphoma and Acute lymphoblastic leukaemia (First-line therapy, Combination therapy) in USA, Australia, Canada, New Zealand and Switzerland (IV) (NCT00408005)
  • 14 Jul 2017 No recent reports on development identified - Phase-I/II for Acute lymphoblastic leukaemia and T-cell lymphoma (Combination therapy, Second-line therapy or greater) in Australia, Canada, Austria, France, Italy, Netherlands, United Kingdom and USA (IV)
  • 04 Jun 2015 Nelarabine is still in phase III development for Acute lymphoblastic leukaemia (Combination therapy, First-line therapy) and T-cell lymphoma (Combination therapy, First-line therapy) in Australia, Canada, New Zealand, Switzerland and USA

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