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Gelsolin - BioAegis Therapeutics

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Drug Profile

Gelsolin - BioAegis Therapeutics

Alternative Names: Gelsolin recombinant; hu r-P gelsolin; pGSN; Recombinant human plasma gelsolin; rh gelsolin; rhu-pGSN; Solinex

Latest Information Update: 29 Aug 2025

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At a glance

  • Originator Brigham and Womens Hospital
  • Developer BioAegis Therapeutics; Critical Biologics Corporation
  • Class Anti-inflammatories; Antibacterials; Antifibrotics; Antineoplastics; Bronchodilators; Expectorants; Proteins
  • Mechanism of Action Interleukin 1 beta inhibitors; Protein replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Adult respiratory distress syndrome; COVID-19 pneumonia; Decompression sickness
  • Phase I/II Community-acquired pneumonia
  • Discontinued Bronchitis; Cystic fibrosis; Systemic inflammatory response syndrome

Most Recent Events

  • 22 Aug 2025 Phase-II clinical trials in Decompression sickness (In volunteers) in USA (IV) (NCT06216366)
  • 20 Aug 2025 Gelsolin - BioAegis Therapeutics receives Fast Track designation for Decompression sickness [IV] (In volunteers) in USA
  • 17 Jun 2025 Gelsolin - BioAegis Therapeutics receives Fast Track designation for Adult respiratory distress syndrome [IV] in USA

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