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Gelsolin - BioAegis Therapeutics

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Drug Profile

Gelsolin - BioAegis Therapeutics

Alternative Names: Gelsolin recombinant; hu r-P gelsolin; pGSN; Recombinant human plasma gelsolin; rh gelsolin; rhu-pGSN; Solinex

Latest Information Update: 29 Feb 2024

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At a glance

  • Originator Brigham and Womens Hospital
  • Developer BioAegis Therapeutics; Critical Biologics Corporation
  • Class Anti-inflammatories; Antibacterials; Antifibrotics; Antineoplastics; Bronchodilators; Expectorants; Proteins
  • Mechanism of Action Interleukin 1 beta inhibitors; Protein replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Adult respiratory distress syndrome; COVID-19 pneumonia
  • Phase I/II Community-acquired pneumonia
  • Preclinical Inflammation
  • Discontinued Bronchitis; Cystic fibrosis; Systemic inflammatory response syndrome

Most Recent Events

  • 27 Feb 2024 Phase-II clinical trials in Adult respiratory distress syndrome in Spain, Netherlands, Italy, Belgium, Germany, Canada, United Kingdom, USA (IV)
  • 16 Oct 2023 BioAegis Therapeutics receives Biomedical Advance Research and Development Authority (BARDA) grant from US Department of Health and Human Services to advance gelsolin for the treatment of Acute respiratory distress syndrome
  • 24 May 2023 BioAegis Therapeutics completes a phase I trial (In volunteers) in USA (IV) (NCT05789745)

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