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Interleukin-2 gene therapy (VCL-IM01)

Drug Profile

Interleukin-2 gene therapy (VCL-IM01)

Alternative Names: Electroporation-delivered DNA immunotherapy against metastatic melanoma - Inovio/Brickell Biotech Inc; IL-2 plasmid DNA/lipid complex (Leuvectin); IL-2-based DNA vaccine - Brickell Biotech Inc; IL-2/EP - Brickell Biotech Inc; Interleukin-2 gene therapy - Brickell Biotech Inc; VCL-1M01; VCL-IM01

Latest Information Update: 06 Sep 2019

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At a glance

  • Originator Vical
  • Developer Inovio Pharmaceuticals; Vical
  • Class Antineoplastics; Cytokine genes; Gene therapies; Interleukins
  • Mechanism of Action Gene transference; Immunostimulants; Interleukin 2 stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Renal cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Malignant melanoma; Prostate cancer; Renal cancer

Most Recent Events

  • 31 Aug 2019 Brickell Biotech has merged with Vical to form Brickell Biotech Inc, and subsequently Brickell Biotech changed its name to Brickell Subsidiary
  • 18 Dec 2008 Final efficacy and adverse events data from a phase I trial in Metastatic melanoma presented at the DNA Vaccines 2008 Conference (DNA Vaccines-2008)
  • 11 Jun 2007 Interim results from a phase I clinical trial in patients with Metastatic melanoma added to the adverse events and Cancer therapeutic trials sections
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