Drug Profile


Alternative Names: AXD-455; CN-1493; CNI 1493; CPSI-2364; Semapimod salt

Latest Information Update: 04 Nov 2017

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At a glance

  • Originator Picower Institute for Medical Research
  • Developer Cytokine PharmaSciences; GPC Biotech AG
  • Class Anti-inflammatories; Hydrazones; Small molecules
  • Mechanism of Action Cytokine inhibitors; HIV replication inhibitors; Immunomodulators; Interleukin 1 inhibitors; Interleukin 6 inhibitors; Mitogen-activated protein kinase inhibitors; Nitric oxide inhibitors; Raf kinase inhibitors; RNA inhibitors; Tumour necrosis factor alpha inhibitors; Tumour necrosis factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • No development reported Autoimmune disorders; Inflammation
  • Discontinued Chemotherapy-induced damage; Crohn's disease; HIV infections; Pancreatitis; Psoriasis

Most Recent Events

  • 24 Jun 2018 Biomarkers information updated
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Autoimmune-disorders(In volunteers) in USA (PO)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Inflammation(In volunteers) in USA (PO)
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