Anti-gonadotrophin releasing hormone vaccine - ML Laboratories/Protherics

Drug Profile

Anti-gonadotrophin releasing hormone vaccine - ML Laboratories/Protherics

Alternative Names: GnRH immunotherapeutic; GnRH vaccine - ML Laboratories/Protherics; GnRHi; O14L; PM-OV-92; Prolog

Latest Information Update: 22 Jun 2004

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At a glance

  • Originator Protherics
  • Class Antiandrogens; Antiprogestogens; Vaccines
  • Mechanism of Action Estrogen receptor antagonists; Gonadotropin releasing hormone inhibitors; Immunostimulants; Progesterone receptor antagonists; Testosterone antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.


Highest Development Phases

  • Discontinued Prostate cancer

Most Recent Events

  • 22 Jun 2004 Discontinued - Phase-II for Prostate cancer in United Kingdom (unspecified route)
  • 09 Jul 2001 Preliminary results of a phase II trial revealed that GnRHi did not elicit large reductions in testosterone levels and ML Laboratories may be about to discontinue the vaccine's development
  • 01 Sep 2000 A phase II study of the new formulation of Prolog® in patients with late-stage prostate cancer is underway in the UK
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