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Lasofoxifene - Sermonix Pharmaceuticals

Drug Profile

Lasofoxifene - Sermonix Pharmaceuticals

Alternative Names: CP-336156; CP-336156-CB; Fablyn; Lasofoxifene tartrate; Oporia

Latest Information Update: 11 Jun 2019

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At a glance

  • Originator Ligand Pharmaceuticals; Pfizer
  • Developer Pfizer; Sermonix Pharmaceuticals
  • Class Antineoplastics; Naphthalenes; Osteoporosis therapies; Pyrrolidines; Small molecules; Tetrahydronaphthalenes
  • Mechanism of Action Cannabinoid receptor CB2 inverse agonists; Estrogen receptor alpha modulators; Estrogen receptor beta agonists; Selective estrogen receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Registered Postmenopausal osteoporosis
  • Preregistration Atrophic vaginitis
  • Phase III Breast cancer
  • Phase II Female sexual dysfunction
  • Research Ovarian cancer
  • No development reported Hypogonadism

Most Recent Events

  • 03 Jun 2019 Pharmacodynamics data from a preclinical trial in Breast cancer presented at the 55th American Society of Clinical Oncology Annual Meeting (ASCO-2019)
  • 28 May 2019 Lasofoxifene - Sermonix Pharmaceuticals receives Fast Track designation for Breast cancer [PO,Tablet] (Late-stage disease, Metastatic disease) in USA
  • 10 Dec 2018 Sermonix Pharmaceuticals plans a phase II trial for Breast cancer (Late-stage disease, Metastatic disease) in early 2019
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