MDNA 55

Drug Profile

MDNA 55

Alternative Names: cpIL4-PE; IL-4 Superkines™; IL4-EC; IL4-PE; Interleukin-4 Empowered Cytokine™; Interleukin-4 PE38KDEL cytotoxin; Interleukin-4 PE38KDEL immunotoxin; Interleukin-4 Pseudomonas toxin; Interleukin-4(38-37)-PE38KDEL; Interleukin-4-Pseudomonas exotoxin; Interleukin-4-Pseudomonas exotoxin fusion protein; INxin; MDNA 55; NBI-3001; PRX321

Latest Information Update: 21 Nov 2017

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At a glance

  • Originator National Institutes of Health (USA); Neurocrine Biosciences
  • Developer Medicenna Therapeutics; Sophiris Bio
  • Class Antineoplastics; Immunotoxins; Recombinant fusion proteins
  • Mechanism of Action Apoptosis stimulants; Immunostimulants; Protein synthesis inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma; Glioma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Glioblastoma
  • Phase I Brain metastases
  • Preclinical Brain cancer; Glioma
  • Research Bladder cancer
  • Discontinued Solid tumours

Most Recent Events

  • 14 Nov 2017 Efficacy and adverse events data from the phase I and phase II trials in Glioblastoma released by Medicenna
  • 24 Oct 2017 Medicenna Therapeutics in-licenses patent for Interleukin-4 Superkines from Stanford University
  • 24 Oct 2017 Stanford University has patent protection for Interleukin-4 Superkines
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