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Bevacizumab - Genentech/Roche

Drug Profile

Bevacizumab - Genentech/Roche

Alternative Names: Avastin; RG-435; rhuMAb-VEGF; RO-4876646

Latest Information Update: 27 Nov 2018

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At a glance

  • Originator Genentech; Hackensack University Medical Center
  • Developer All Ireland Cooperative Oncology Research Group; Austrian Breast & Colorectal Cancer Study Group; Bayer; Beth Israel Deaconess Medical Center; Breast Cancer Research Foundation; Brigham and Women's Hospital; Bristol-Myers Squibb; Cancer and Leukemia Group B; Cancer Research UK; Chugai Pharmaceutical; Cincinnati Children's Hospital Medical Center; Dana-Farber Cancer Institute; Duke University; European Organisation for Research and Treatment of Cancer; European Thoracic Oncology Platform; Genentech; Hackensack University Medical Center; Hoosier Cancer Research Network; Indiana University School of Medicine; Japan Breast Cancer Research Group; M. D. Anderson Cancer Center; Massachusetts General Hospital; Medical University of South Carolina; Melanoma Research Foundation Breakthrough Consortium; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); National Comprehensive Cancer Network; NCIC Clinical Trials Group; North Central Cancer Treatment Group; NSABP Foundation; Ohio State University Medical Center; Peter MacCallum Cancer Centre; Roche; Royal Marsden NHS Foundation Trust; Sanofi; Sarcoma Alliance for Research through Collaboration; SCRI Development Innovations; South Eastern European Research Oncology Group; Spanish Cooperative Group for Digestive Tumour Therapy; Spanish Lung Cancer Group; Stanford University School of Medicine; SWOG; The Catalan Institute of Oncology; UNICANCER; University College London; University of Alabama at Birmingham; University of Arkansas System; University of California, Davis; University of Iowa; University of Oklahoma; University of Tennessee; University of Texas M. D. Anderson Cancer Center; US Oncology Research; West German Study Group; Xijing Hospital
  • Class Antineoplastics; Eye disorder therapies; Monoclonal antibodies
  • Mechanism of Action Angiogenesis inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma; Mesothelioma; Cervical cancer; Ovarian cancer; Pancreatic cancer; Renal cell carcinoma; Glioma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Breast cancer; Cervical cancer; Colorectal cancer; Glioblastoma; Glioma; Non-small cell lung cancer; Ovarian cancer; Renal cell carcinoma
  • Registered Fallopian tube cancer; Peritoneal cancer
  • Phase III Head and neck cancer
  • Phase II Biliary cancer; Brain metastases; Endometrial cancer; Ewing's sarcoma; Gynaecological cancer; Hodgkin's disease; Intestinal cancer; Liver cancer; Liver metastases; Malignant melanoma; Meningioma; Multiple myeloma; Neuroblastoma; Neurofibromatoses; Rectal cancer; Soft tissue sarcoma; Solid tumours; Urogenital cancer
  • Phase I/II Neoplastic meningitis; Sarcoma
  • Suspended Carcinoid tumour
  • Discontinued Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Eye disorders; Gastric cancer; Gastrointestinal stromal tumours; Mesothelioma; Oesophageal cancer; Pancreatic cancer; Prostate cancer; Small cell lung cancer

Most Recent Events

  • 15 Nov 2018 Hoffmann-La Roche withdraws a phase III trial prior to recruitment in Renal cell carcinoma as Roche has determined not to generate additional safety data in Renal cell carcinoma patients (NCT03693573)
  • 02 Nov 2018 Genentech and Memorial Sloan Kettering Cancer Center completes a phase-II clinical trial in Neuroblastoma (Combination therapy, Late-stage disease, Recurrent, Second-line therapy or greater, In children, In adults, In adolescents) in USA (IV) (NCT01114555)
  • 31 Oct 2018 Roche completes the phase II BELIEF trial for Non-small cell lung cancer (Combination therapy, Late-stage disease, EGFR-positive) in United Kingdom, France, Germany, Greece, Ireland, Italy, Spain and Switzerland (IV) (NCT01562028)
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