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CDX 301

Drug Profile

CDX 301

Alternative Names: CDX-301; Flt-3 ligand; Flt3-L; Fms-like tyrosine kinase 3 ligand - Celldex Therapeutics; Mobista; rhuFlt3L; Vaccine-adjuvant-Amgen; Vaccine-adjuvant-Celldex-Therapeutics; Vaccine-adjuvant-FLT-3-ligand; Vaccine-adjuvant-Immunex

Latest Information Update: 28 Apr 2024

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At a glance

  • Originator Amgen
  • Developer Albert Einstein College of Medicine; Amgen; Celldex Therapeutics Inc; Dana-Farber Cancer Institute; Icahn School of Medicine at Mount Sinai; Merck Sharp & Dohme; Washington University School of Medicine
  • Class Adjuvants; Antineoplastics; Antiretrovirals; Cytokines; Immunotherapies; Recombinant proteins
  • Mechanism of Action Fms-like tyrosine kinase 3 stimulants; Haematopoiesis stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Non-small cell lung cancer; Pancreatic cancer
  • Phase I/II B-cell lymphoma; Breast cancer; Head and neck cancer; Non-Hodgkin's lymphoma
  • Phase I Malignant melanoma; Prostate cancer; Triple negative breast cancer
  • No development reported HIV infections; Lymphoma; Solid tumours
  • Discontinued Autoimmune disorders; Infections; Stem cell mobilisation

Most Recent Events

  • 28 Apr 2024 No recent reports of development identified for preclinical development in HIV-infections in USA
  • 21 Nov 2023 Washington University School of Medicine, in collaboration with Celldex Therapeutics and The Foundation for Barnes-Jewish Hospital terminates a phase II trial in Pancreatic cancer (Combination therapy) in USA (IV; infusion) due to Celldex decision (NCT04536077)
  • 23 Jun 2023 Albert Einstein College of Medicine and Celldex Therapeutics terminates phase I/II trials in Non-small cell lung cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in USA due to low accural (Parenteral) (NCT04491084)
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