Fms-like tyrosine kinase 3 ligand - Celldex Therapeutics

Drug Profile

Fms-like tyrosine kinase 3 ligand - Celldex Therapeutics

Alternative Names: CDX-301; Flt-3 ligand; Flt3-L; Mobista; rhuFlt3L

Latest Information Update: 11 Jun 2018

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At a glance

  • Originator Amgen
  • Developer Albert Einstein College of Medicine; Amgen; Celldex Therapeutics Inc; Icahn School of Medicine at Mount Sinai
  • Class Adjuvants; Antineoplastics; Cytokines; Recombinant proteins
  • Mechanism of Action Dendritic cell stimulants; Fms-like tyrosine kinase 3 stimulants; Haematopoiesis stimulants; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Non-small cell lung cancer
  • Phase I/II B cell lymphoma
  • Discontinued Autoimmune disorders; Infections; Malignant melanoma; Non-Hodgkin's lymphoma; Solid tumours; Stem cell mobilisation

Most Recent Events

  • 11 Jun 2018 Discontinued - Phase-II for Malignant melanoma (Combination therapy, Inoperable/Unresectable, Late-stage disease) in USA (Parenteral)
  • 10 May 2018 Interim efficacy data from a phase II trial in Non-small cell lung cancer released by Celldex Therapeutics
  • 11 Dec 2017 Celldex Therapeutics plans to initiate the phase I FLIGHT trial for Malignant melanoma (Combination therapy, Inoperable/Unresectable, Second-line therapy or greater, Metastatic disease) in Australia (ACTRN12617001621303)
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