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Atrasentan - Chinook Therapeutics

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Drug Profile

Atrasentan - Chinook Therapeutics

Alternative Names: A 147627; A-1476271; Abbott 147627; ABT-147627; ABT-627; Atrasentan hydrochloride; CHK-01; EXV-811; Vanrafia; Xinlay

Latest Information Update: 18 Feb 2026

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At a glance

  • Originator Abbott Laboratories
  • Developer Abbott Laboratories; AbbVie; Chinook Therapeutics
  • Class Amides; Anti-inflammatories; Antineoplastics; Benzodioxoles; Carboxylic acids; Ethers; Heart failure therapies; Pyrrolidines; Small molecules; Toluenes; Vascular disorder therapies
  • Mechanism of Action Endothelin A receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Nephrotic syndrome; IgA nephropathy
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed IgA nephropathy
  • Phase III Atherosclerosis
  • Phase II Diabetic nephropathies; Focal segmental glomerulosclerosis; Hereditary nephritis
  • Discontinued Adenocarcinoma; Brain cancer; Coronary artery restenosis; Heart failure; Lung cancer; Ovarian cancer; Prostate cancer; Renal cancer

Most Recent Events

  • 13 Feb 2026 Novartis plans to submit for traditional approval for IgA Nephropathy in 2026
  • 13 Feb 2026 Final efficacy and adverse events data from a phase III ALIGN trial in IgA nephropathy released by Novartis
  • 22 Jan 2026 Novartis initiates a Managed Access Program for IgA nephropathy (PO) (NCT07319585)

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