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Atrasentan - Abbvie

Drug Profile

Atrasentan - Abbvie

Alternative Names: A 147627; A-1476271; Abbott 147627; ABT-147627; ABT-627; Atrasentan hydrochloride; Xinlay

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Abbott Laboratories
  • Developer Abbott Laboratories; AbbVie
  • Class Amides; Antineoplastics; Benzodioxoles; Carboxylic acids; Pyrrolidines; Small molecules
  • Mechanism of Action Endothelin A receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Diabetic nephropathies
  • Discontinued Brain cancer; Coronary artery restenosis; Heart failure; Lung cancer; Ovarian cancer; Prostate cancer; Renal cancer

Most Recent Events

  • 12 Jul 2018 AbbVie completes a phase II trial for Diabetes nephropathies in Germany, Italy, Spain, USA(NCT02118714)
  • 24 Jun 2018 Biomarkers information updated
  • 01 Dec 2017 AbbVie terminates the phase III SONAR trial in Diabetic nephropathies (Adjunctive treatment) in USA, United Kingdom, Taiwan, Canada, Japan, Puerto Rico, Ukraine, Turkey, Switzerland, Sweden, Spain, South Africa, Slovakia, Singapore, Russia, Romania, Portugal, Poland, Peru, New Zealand, Mexico, Netherlands, Malaysia, South Korea, Italy, Israel, Ireland, Hong Kong, Greece, Germany, France, Finland, Denmark, Czech Republic, China, Chile, Brazil, Belgium, Argentina, Australia and Austria (PO) (NCT01858532)
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