Atrasentan - Abbvie

Drug Profile

Atrasentan - Abbvie

Alternative Names: A 147627; A-1476271; Abbott 147627; ABT-147627; ABT-627; Atrasentan hydrochloride; Xinlay

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Abbott Laboratories
  • Developer Abbott Laboratories; AbbVie
  • Class Amides; Antineoplastics; Benzodioxoles; Carboxylic acids; Pyrrolidines; Small molecules
  • Mechanism of Action Endothelin A receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Diabetic nephropathies
  • Discontinued Brain cancer; Coronary artery restenosis; Heart failure; Lung cancer; Ovarian cancer; Prostate cancer; Renal cancer

Most Recent Events

  • 01 Dec 2017 AbbVie terminates the phase III SONAR trial in Diabetic nephropathies (Adjunctive treatment) in USA, United Kingdom, Taiwan, Canada, Japan, Puerto Rico, Ukraine, Turkey, Switzerland, Sweden, Spain, South Africa, Slovakia, Singapore, Russia, Romania, Portugal, Poland, Peru, New Zealand, Mexico, Netherlands, Malaysia, South Korea, Italy, Israel, Ireland, Hong Kong, Greece, Germany, France, Finland, Denmark, Czech Republic, China, Chile, Brazil, Belgium, Argentina, Australia and Austria (PO) (NCT01858532)
  • 15 Dec 2016 Biomarkers information updated
  • 28 Sep 2016 Efficacy data from the phase II S0421 trial in Prostate cancer presented at the 41st European Society for Medical Oncology Congress (ESMO-2016)
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