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Onabotulinum toxin A - AbbVie

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Drug Profile

Onabotulinum toxin A - AbbVie

Alternative Names: BoNTA; Botox; Botulinum toxin A injectable-AbbVie; GSK 1358820; OnabotA X; OnabotulinumtoxinA X; Vistabel; Vistabex

Latest Information Update: 31 May 2024

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At a glance

  • Originator Allergan
  • Developer AbbVie; Allergan; GlaxoSmithKline; GSK; Johns Hopkins University; Queens University; Temple University; University of Illinois at Chicago; Wake Forest University School of Medicine
  • Class Analgesics; Anti-inflammatories; Antiarrhythmics; Antidepressants; Antimigraines; Antipruritics; Antispasmodics; Bacterial proteins; Bacterial toxins; Botulinum toxins; Eye disorder therapies; Foot disorder therapies; Muscle relaxants; Recombinant proteins; Skin disorder therapies; Urologics; Vascular disorder therapies
  • Mechanism of Action Acetylcholine inhibitors; Glutamate antagonists; Membrane transport protein modulators; Neuromuscular blocking agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Strabismus; Muscle spasticity; Blepharospasm; Torticollis
  • New Molecular Entity No

Highest Development Phases

  • Marketed Blepharospasm; Dysphonia; Facial wrinkles; Glabellar lines; Hyperhidrosis; Migraine; Muscle spasticity; Neurogenic bladder; Overactive bladder; Strabismus; Torticollis
  • Registered Equinus foot deformity
  • Preregistration Hypertrophy
  • Phase III Muscle pain; Raynaud's disease
  • Phase II Carpal tunnel syndrome; Essential tremor; Gastrointestinal disorders; Herpes labialis; Interstitial cystitis; Major depressive disorder; Musculoskeletal pain; Neuropathic pain; Pain; Premature ejaculation
  • Phase I/II Pruritus
  • No development reported Benign prostatic hyperplasia; Constipation; Prostatitis
  • Discontinued Diabetic gastroparesis; Gilles de la Tourette's syndrome

Most Recent Events

  • 16 May 2024 AbbVie withdraws a phase II trial in Hernia in USA (IM, Injection) due to strategic considerations (NCT05606757)
  • 30 Apr 2024 Phase-III clinical trials in Hypertrophy in USA (IM) (NCT06399718)
  • 16 Feb 2024 Preregistration for Hypertrophy in China (IM), before February 2024 (AbbVie pipeline, February 2024)
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