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Alpha-antitrypsin - PPL Therapeutics

Drug Profile

Alpha-antitrypsin - PPL Therapeutics

Alternative Names: AAT - PPL Therapeutics; Alpha-1 proteinase inhibitor - PPL Therapeutics; Alpha-1-antitrypsin - PPL Therapeutics; rAAT - PPL Therapeutics; recAAT - PPL Therapeutics; Recombinant AAT; TgAAT - PPL Therapeutics

Latest Information Update: 22 Mar 2010

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At a glance

  • Originator PPL Therapeutics PLC
  • Developer Bayer; PPL Therapeutics PLC
  • Class Acute-phase proteins; Alpha globulins; Anti-inflammatories; Blood proteins; Secretory proteinase inhibitory proteins; Serpins
  • Mechanism of Action Leucocyte elastase inhibitors; Peptide hydrolase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.


Highest Development Phases

  • Discontinued Adult respiratory distress syndrome; Alpha 1-antitrypsin deficiency; Cystic fibrosis

Most Recent Events

  • 15 Mar 2016 Biomarkers information updated
  • 10 Jul 2003 Suspended - Clinical-Phase-Unknown for Alpha 1-antitrypsin deficiency in United Kingdom (IV)
  • 10 Jul 2003 Suspended - Phase-II for Alpha 1-antitrypsin deficiency in United Kingdom (Inhalation)
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