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Erlotinib - Astellas Pharma/Roche

Drug Profile

Erlotinib - Astellas Pharma/Roche

Alternative Names: CP-358774; CP-358774-01; Erlotinib hydrochloride; NSC-718781; OSI-774; R-1415; RG-1415; RO-508231; Ro50-8231; Tarceva

Latest Information Update: 18 Dec 2018

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At a glance

  • Originator OSI Pharmaceuticals
  • Developer Alliance for Clinical Trials in Oncology; Astellas Pharma; Chugai Pharmaceutical; European Thoracic Oncology Platform; Finnish Lung Cancer Group; Genentech; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); Novartis; OSI Pharmaceuticals; Polyphenon Pharma; Roche; SCRI Development Innovations; Takeda Oncology; University of Texas M. D. Anderson Cancer Center; Wake Forest University School of Medicine
  • Class Alkynes; Antineoplastics; Quinazolines; Small molecules
  • Mechanism of Action Epidermal growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer; Pancreatic cancer
  • Phase III Ependymoma; Head and neck cancer
  • Phase II Bladder cancer; Brain metastases; Glioblastoma; Gynaecological cancer; Neuroendocrine tumours; Squamous cell cancer
  • Phase I/II Colorectal cancer; Myelodysplastic syndromes
  • Phase I Solid tumours
  • No development reported Anaplastic astrocytoma; Breast cancer; Bronchiolo-alveolar adenocarcinoma; Cancer metastases
  • Discontinued Liver cancer

Most Recent Events

  • 08 Nov 2018 Memorial Sloan Kettering Cancer Center and Astellas Pharma complete a phase I trial in Non-small cell lung cancer (Late-stage disease, Recurrent) in USA (PO) (NCT01967095)
  • 31 Oct 2018 Roche completes the phase II BELIEF trial for Non-small cell lung cancer (Combination therapy, Late-stage disease, EGFR-positive) in United Kingdom, France, Germany, Greece, Ireland, Italy, Spain and Switzerland (PO) (NCT01562028)
  • 24 Jun 2018 Biomarkers information updated
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