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Drug Profile


Alternative Names: MSI-1436; Produlestan; Trodulamine

Latest Information Update: 18 Jul 2019

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At a glance

  • Originator Genaera Corporation
  • Developer DepYmed; Genaera Corporation; North Shore-Long Island Jewish Health System
  • Class Anorectics; Antihyperglycaemics; Antivirals; Biogenic amines; Cholestanes; Obesity therapies; Polyamines
  • Mechanism of Action Adrenergic uptake inhibitors; Apoptosis stimulants; Dopamine uptake inhibitors; Neuropeptide Y modulators; Protein-tyrosine-phosphatase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • No development reported Breast cancer
  • Discontinued Diabetes mellitus; HIV infections; Obesity; Type 2 diabetes mellitus

Most Recent Events

  • 12 Jul 2019 Ohr Pharmaceutical has merged with NeuBase Therapeutics to form NeuBase Therapeutics
  • 28 May 2019 No recent reports of development identified for phase-I development in Breast-cancer(Metastatic disease, Second-line therapy or greater) in USA (IV)
  • 14 May 2018 DepYmed terminates a phase I trial in Breast cancer (Metastatic disease, Second-line therapy or greater) in USA due to lack of interest by sponsor (IV) (NCT02524951)
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