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Nitric oxide - Mallinckrodt

Drug Profile

Nitric oxide - Mallinckrodt

Alternative Names: Ik 7001; IK-3001; IK-7001; INOflo; INOmax; INOmax Total Care; INOMAX® Total Care package; INOtherapy; INOVENT

Latest Information Update: 06 May 2020

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At a glance

  • Originator Massachusetts General Hospital
  • Developer AGA Linde Healthcare; Ikaria Holdings; Mallinckrodt plc; Massachusetts General Hospital
  • Class Anti-inflammatories; Antiacnes; Antiandrogens; Antibacterials; Antifibrotics; Antifungals; Antihypertensives; Antivirals; Cardiovascular therapies; Diagnostic agents; Free radicals; Nitrogen oxides; Non-opioid analgesics; Small molecules; Vasodilators
  • Mechanism of Action Androgen receptor antagonists; Angiogenesis inducing agents; Cell death stimulants; Guanylate cyclase stimulants; Nitric oxide donors; Reactive oxygen species modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pulmonary hypertension; Hypoxic respiratory failure
  • New Molecular Entity No

Highest Development Phases

  • Marketed Hypoxic respiratory failure; Pulmonary hypertension
  • Phase III Bronchopulmonary dysplasia; Pulmonary arterial hypertension
  • Clinical Phase Unknown Adult respiratory distress syndrome; Coronavirus infections
  • Preclinical Transplant rejection
  • Discontinued Heart failure; Reperfusion injury

Most Recent Events

  • 30 Apr 2020 Massachusetts General Hospital initiates enrolment in a clinical trial for Adult respiratory distress syndrome in USA
  • 12 Mar 2020 Clinical trials in Coronavirus infections before March 2020 (Inhalation)
  • 12 Mar 2020 Preclinical trials in Acute respiratory distress syndrome infections in United Kingdom (Inhalation)
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