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Antithrombin alfa - rEVO Biologics

Drug Profile

Antithrombin alfa - rEVO Biologics

Alternative Names: Antithrombin III recombinant human; Antithrombin III transgenic; ATryn; Recombinant human antithrombin III; rhATIII; Transgenic antithrombin III

Latest Information Update: 25 Sep 2021

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At a glance

  • Originator GTC Biotherapeutics
  • Developer GTC Biotherapeutics; Knight Therapeutics; LEO Pharma; rEVO Biologics
  • Class Alpha globulins; Anticoagulants; Antithrombins; Antithrombotics; Recombinant proteins
  • Mechanism of Action Thrombin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Blood coagulation disorders; Antithrombin III deficiency
  • New Molecular Entity Yes
  • Available For Licensing Yes - Antithrombin III deficiency; Blood coagulation disorders

Highest Development Phases

  • Marketed Antithrombin III deficiency
  • Phase III Blood coagulation disorders; Preeclampsia
  • Discontinued Acute lung injury; Burns; Disseminated intravascular coagulation; Solid tumours

Most Recent Events

  • 15 Apr 2021 No development reported - Preregistration for Antithrombin III deficiency in Canada (IV)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Coagulation-disorders(In neonates) in USA (Parenteral)
  • 01 Nov 2016 rEVO Biologics completes a phase III trial in Preeclampsia in USA (IV) (NCT02059135)
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