Drug Profile


Alternative Names: DB-289; Parfuramidine maleate

Latest Information Update: 28 Aug 2014

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At a glance

  • Originator Georgia State University; University of North Carolina at Chapel Hill
  • Developer CombinatoRx; Immtech Pharmaceuticals
  • Class Antiparasitics; Benzamidines; Small molecules
  • Mechanism of Action DNA inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pneumocystis pneumonia; Malaria; Trypanosomiasis

Highest Development Phases

  • Discontinued Cancer; Malaria; Pneumocystis pneumonia; Trypanosomiasis

Most Recent Events

  • 01 Aug 2014 TopoTarget has merged with BioAlliance Pharma to form Onxeo SA
  • 22 Feb 2008 Immtech Pharmaceuticals has discontinued all development programmes for pafuramidine in response to additional adverse events identified in a cohort of subjects in a safety study of the drug
  • 26 Dec 2007 Suspended - Phase-II for Malaria prevention in USA (PO)
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