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Zibotentan - AstraZeneca

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Drug Profile

Zibotentan - AstraZeneca

Alternative Names: AZD 4054; ZD4054

Latest Information Update: 31 Jul 2019

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At a glance

  • Originator AstraZeneca
  • Class Antineoplastics; Oxadiazoles; Pyrazines; Pyridines; Small molecules; Sulfonamides
  • Mechanism of Action Endothelin A receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Breast cancer; Colorectal cancer; Heart failure; Non-small cell lung cancer; Ovarian cancer; Prostate cancer

Most Recent Events

  • 24 Jun 2018 Biomarkers information updated
  • 18 May 2018 AstraZeneca withdraws the phase II PLANET trial prior to enrolment for Breast cancer (Combination therapy, Second-line therapy or greater, Late-stage disease, Metastatic disease) in United Kingdom as new information on IMP affected the cost/benefit ratio (PO) (NCT01134497)
  • 31 Dec 2012 Discontinued - Phase-III for Prostate cancer in Canada (PO)
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