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Drug Profile


Alternative Names: GYKI-53773; LY-300164

Latest Information Update: 29 Jul 2015

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At a glance

  • Originator IVAX Drug Research Institute
  • Developer Teva Pharmaceutical Industries
  • Class Antiepileptic drugs; Antineoplastics; Neuroprotectants; Small molecules
  • Mechanism of Action AMPA receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Amyotrophic lateral sclerosis; Dyskinesias; Epilepsy; Glioblastoma; Multiple sclerosis

Most Recent Events

  • 23 Jun 2010 Discontinued - Phase-II for Glioblastoma in USA (PO)
  • 08 Jun 2010 Teva Pharmaceutical Industries terminates phase II trial [NCT00982150] in Amyotrophic Lateral Sclerosis in the USA, Canada, EU and Israel
  • 18 May 2010 Interim efficacy and adverse event data from a phase II trial in Amyotrophic lateral sclerosis released by Teva
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