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Lonafarnib - Eiger Biopharmaceuticals

Drug Profile

Lonafarnib - Eiger Biopharmaceuticals

Alternative Names: EBP 994; MK-6336; Sarasar; SCH 066336; SCH 66336; Zokinvy

Latest Information Update: 25 Sep 2021

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At a glance

  • Originator Schering-Plough
  • Developer Eiger BioPharmaceuticals, Inc.; Merck & Co; Schering-Plough
  • Class Amides; Antineoplastics; Antivirals; Benzene derivatives; Halogenated hydrocarbons; Piperidines; Pyridines; Small molecules
  • Mechanism of Action Farnesyltranstransferase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Progeria; Hepatitis D
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Progeria
  • Phase III Hepatitis D
  • Discontinued Breast cancer; Cancer; Chronic myelomonocytic leukaemia; Glioblastoma; Glioma; Leukaemia; Myelodysplastic syndromes; Non-small cell lung cancer; Pancreatic cancer; Solid tumours; Squamous cell cancer

Most Recent Events

  • 30 Jun 2021 Biomarkers information updated
  • 23 Jun 2021 Efficacy data from the phase III D-LIVR trial in Hepatitis D presented at the International Liver Congress (ILC-2021)
  • 06 May 2021 Eiger Biopharmaceuticals expected to receive EMA approval for Progeria by 2021
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