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Collagenase clostridium histolyticum - BioSpecifics Technologies Corporation/Endo, Inc.

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Drug Profile

Collagenase clostridium histolyticum - BioSpecifics Technologies Corporation/Endo, Inc.

Alternative Names: AA-4500; AK-160; CCH; Clostridial collagenase; Collagenase clostridium histolyticum-aaes; Cordase; EN-3835; PF-5076985; Plaquase; Qwo; XIAFLEX; Xiapex

Latest Information Update: 31 Jul 2025

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At a glance

  • Originator BioSpecifics Technologies Corporation
  • Developer Actelion Pharmaceuticals; Asahi Kasei; BioSpecifics Technologies Corporation; Endo International; Endo, Inc.; Swedish Orphan Biovitrum
  • Class Antineoplastics; Collagenases; Skin disorder therapies; Urologics
  • Mechanism of Action Collagenase replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Dupuytren's contracture; Peyronie's disease
  • New Molecular Entity No

Highest Development Phases

  • Marketed Cellulite; Dupuytren's contracture; Peyronie's disease
  • Phase III Fibroma
  • Phase II Frozen shoulder; Lipoma; Plantar fasciitis
  • No development reported Breast disorders; Metabolic disorders; Uterine leiomyoma
  • Discontinued Hypertrophic scars; Keloids; Tendon injuries

Most Recent Events

  • 24 Jul 2025 Efficacy and adverse events data from a phase I trial in Plantar fasciitis released by Endo Pharmaceuticals
  • 05 Nov 2024 Efficacy data from a phase II trial in Plantar fasciitis released by Endo
  • 08 Aug 2024 Efficacy and adverse event data from a phase-II trial in Fibroma released by Endo International

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