Collagenase injection - BioSpecifics Technologies Corporation

Drug Profile

Collagenase injection - BioSpecifics Technologies Corporation

Alternative Names: AA-4500; AK-160; CCH; Clostridial collagenase; Collagenase clostridium histolyticum; Cordase; EN-3835; PF-5076985; Plaquase; XIAFLEX; Xiapex

Latest Information Update: 17 Aug 2018

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At a glance

  • Originator BioSpecifics Technologies Corporation
  • Developer Actelion Pharmaceuticals; Asahi Kasei; BioSpecifics Technologies Corporation; Endo International; Swedish Orphan Biovitrum
  • Class Collagenases; Urologics
  • Mechanism of Action Collagen inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Dupuytren's contracture; Peyronie's disease
  • New Molecular Entity No
  • Available For Licensing Yes - Dupuytren's contracture; Peyronie's disease

Highest Development Phases

  • Marketed Dupuytren's contracture; Peyronie's disease
  • Phase III Cellulite
  • Phase II Frozen shoulder; Lipoma
  • Phase I Uterine leiomyoma
  • Preclinical Breast disorders
  • Research Metabolic disorders; Musculoskeletal disorders
  • Discontinued Hypertrophic scars; Keloids; Tendon injuries

Most Recent Events

  • 18 Sep 2018 Endo Pharmaceuticals plans a phase I trial for Cellulite (In volunteers) in October 2018 (SC, Injection) (NCT03675685)
  • 16 Aug 2018 Endo Pharmaceuticals plans a phase II trial for Oedema (skin) in August 2018 (NCT03632993)
  • 09 Aug 2018 BioSpecifics completes enrolment in its Phase-I clinical trials in Uterine leiomyoma in USA (Injection) (NCT02889848)
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