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NS 2359

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Drug Profile

NS 2359

Alternative Names: 372475; GSK 372475

Latest Information Update: 11 Nov 2020

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At a glance

  • Originator NeuroSearch
  • Developer National Institute on Drug Abuse; Saniona; University of Pennsylvania
  • Class Antidepressants; Drug withdrawal therapies; Nootropics; Small molecules
  • Mechanism of Action Adrenergic uptake inhibitors; Dopamine uptake inhibitors; Serotonin uptake inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Cocaine-related disorders
  • Discontinued Alcoholism; Attention-deficit hyperactivity disorder; Major depressive disorder

Most Recent Events

  • 05 Nov 2020 Saniona and University of Pennsylvania, Treatment Research Center (TRC) discontinue the research collaboration to develop NS 2359 in Cocaine Cocaine-related disorders
  • 07 Oct 2020 Saniona, University of Pennsylvania and the Dana Foundation completes a phase II trial for Cocaine abuse in USA (PO) (NCT02798627)
  • 23 Jan 2019 The University of Pennsylvania Treatment Research Center (TRC) plans to continue the ongoing phase II study for NS 2359 in cocaine addiction at a higher dose
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