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Mepolizumab - GlaxoSmithKline

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Drug Profile

Mepolizumab - GlaxoSmithKline

Alternative Names: 240563; Bosatria; Mepolizamab; Nucala; SB-240563

Latest Information Update: 01 Apr 2024

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At a glance

  • Originator GlaxoSmithKline
  • Developer GlaxoSmithKline; GSK; McMaster University; National Institute of Allergy and Infectious Diseases
  • Class Anti-inflammatories; Antiallergics; Antiasthmatics; Monoclonal antibodies; Skin disorder therapies
  • Mechanism of Action Interleukin 5 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hypereosinophilic syndrome; Churg-Strauss syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Asthma; Nasal polyps
  • Registered Churg-Strauss syndrome; Hypereosinophilic syndrome
  • Preregistration Chronic obstructive pulmonary disease
  • Phase II Eosinophilic oesophagitis
  • Discontinued Atopic dermatitis

Most Recent Events

  • 23 Feb 2024 Efficacy and pharmacokinetics from the phase III long term access trial for Churg-Strauss syndrome presented at the 2024 Annual Meeting of the American Academy of Allergy, Asthma and Immunology (AAAAI-2024)
  • 23 Feb 2024 Updated efficacy data from the phase-III SYNAPSE trial in Nasal Polyps presented at the Annual Meeting of the American Academy of Allergy, Asthma and Immunology (AAAAI-2024)
  • 26 Jul 2023 Preregistration for Asthma in China (SC) prior to July 2023

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