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Mepolizumab - GlaxoSmithKline

Drug Profile

Mepolizumab - GlaxoSmithKline

Alternative Names: 240563; Bosatria; Mepolizamab; Nucala; SB-240563

Latest Information Update: 22 Nov 2018

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At a glance

  • Originator GlaxoSmithKline
  • Developer GlaxoSmithKline; McMaster University; National Institute of Allergy and Infectious Diseases
  • Class Anti-inflammatories; Antiallergics; Antiasthmatics; Monoclonal antibodies; Skin disorder therapies
  • Mechanism of Action Interleukin 5 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hypereosinophilic syndrome; Churg-Strauss syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Asthma
  • Registered Churg-Strauss syndrome
  • Preregistration Chronic obstructive pulmonary disease
  • Phase III Hypereosinophilic syndrome; Nasal polyps
  • Phase II Atopic dermatitis
  • No development reported Eosinophilic oesophagitis

Most Recent Events

  • 19 Nov 2018 Preregistration for Asthma (In children, Adjunctive treatment) in USA (SC)
  • 13 Sep 2018 Phase-III clinical trials in Asthma (Adjunctive treatment, In adolescents, In adults) in China (SC) (NCT03562195)
  • 10 Sep 2018 Registered for Churg-Strauss syndrome (Adjunctive treatment) in Canada (SC)
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