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Drug Profile


Alternative Names: 5c8; 5c8 humanised monoclonal antibody; Anti-CD154 monoclonal antibody; Anti-CD40 ligand antibody; Anti-CD40 ligand monoclonal antibody; Anti-CD40 ligand monoclonal antibody 5c8; Anti-gp39 monoclonal antibody - Biogen; Antova; BG 9588; CD40 ligand monoclonal antibody - Biogen; hu5c8; Humanised CD40 ligand antibody/5c8; T cell-B cell activation molecule; T-BAM

Latest Information Update: 07 Mar 2007

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At a glance

  • Originator Biogen
  • Class Monoclonal antibodies
  • Mechanism of Action CD40 ligand inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Autoimmune disorders; Haemophilia A; Idiopathic thrombocytopenic purpura; Multiple sclerosis; Renal transplant rejection; Systemic lupus erythematosus

Most Recent Events

  • 28 Aug 2001 A study has been added to the adverse events and Transplant Rejection therapeutic trials sections
  • 22 Aug 2001 Anti-CD40 ligand monoclonal antibody 5c8 is now called Ruplizumab
  • 28 Apr 2000 A clinical study has been added to the therapeutic trials section of haematology
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