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Tocilizumab - Chugai Pharmaceutical/Roche

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Drug Profile

Tocilizumab - Chugai Pharmaceutical/Roche

Alternative Names: Actemra; ACTPen; Anti-IL-6 receptor antibody - Chugai; Anti-interleukin-6 receptor antibody - Chugai; Atlizumab; HPM-1; MRA; MRA - Chugai; MRA-SC; R-1569; RG-1569; rhPM-1; RO4877533; RoActemra

Latest Information Update: 07 May 2024

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At a glance

  • Originator Chugai Pharmaceutical; Osaka University
  • Developer Assistance Publique Hopitaux de Paris; Biomedical Advanced Research and Development Authority; Charite - Universitatsmedizin Berlin; Chugai Pharmaceutical; Hospital for Special Surgery; JW Pharmaceutical; Roche; University Hospital Inselspital; University Hospital Tubingen; University of Bern; University of Pittsburgh
  • Class Anti-inflammatories; Antineoplastics; Antirheumatics; Immunotherapies; Monoclonal antibodies; Skin disorder therapies; Vascular disorder therapies
  • Mechanism of Action Interleukin 6 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Drug hypersensitivity; Giant lymph node hyperplasia; Vasculitis; Systemic scleroderma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed COVID 2019 infections; COVID-19 pneumonia; Drug hypersensitivity; Giant cell arteritis; Giant lymph node hyperplasia; Juvenile rheumatoid arthritis; Rheumatoid arthritis; Systemic scleroderma
  • Registered Adult-onset Still's disease; Vasculitis
  • Phase III Osteoarthritis
  • Phase II Amyotrophic lateral sclerosis; Dermatomyositis; Familial Mediterranean fever; Polymyalgia rheumatica; Polymyositis; Pulmonary arterial hypertension; Schnitzler syndrome
  • Phase I/II Urogenital cancer
  • Phase I Pancreatic cancer
  • No development reported Chronic lymphocytic leukaemia
  • Discontinued Ankylosing spondylitis; Crohn's disease; Multiple myeloma; Systemic lupus erythematosus

Most Recent Events

  • 27 Mar 2024 Roche completes phase-I clinical trials in COVID-2019 infections (Adjunctive treatment, In infants, In children, In adolescents, In neonates) in US, Brazil, Croatia, France, Germany, Spain, Italy , Poland, South Africa, UK and Greece (IV) (NCT05164133)
  • 13 Sep 2023 Regulatory submission withdrawn for Systemic scleroderma in European Union (SC)
  • 09 May 2023 Registered for COVID-19 pneumonia in Taiwan (IV) before May 2023 (Chugai Pharmaceuticals pipeline, May 2023)
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