Tocilizumab - Roche

Drug Profile

Tocilizumab - Roche

Alternative Names: Actemra; Anti-IL-6 receptor antibody - Chugai; Anti-interleukin-6 receptor antibody - Chugai; Atlizumab; HPM-1; MRA; MRA - Chugai; MRA-SC; R-1569; RG-1569; rhPM-1; RO4877533; RoActemra

Latest Information Update: 17 Sep 2018

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At a glance

  • Originator Chugai Pharmaceutical; Osaka University
  • Developer Assistance Publique Hopitaux de Paris; Charite - Universitatsmedizin Berlin; Chugai Pharmaceutical; Hospital for Special Surgery; JW Pharmaceutical; Roche; University Hospital Inselspital; University Hospital Tubingen; University of Bern; University of Pittsburgh
  • Class Antirheumatics; Monoclonal antibodies
  • Mechanism of Action Immunosuppressants; Interleukin 6 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Drug hypersensitivity; Giant lymph node hyperplasia; Vasculitis; Systemic scleroderma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Giant cell arteritis; Giant lymph node hyperplasia; Juvenile rheumatoid arthritis; Rheumatoid arthritis
  • Registered Drug hypersensitivity; Vasculitis
  • Preregistration Adult-onset Still's disease
  • Phase III Osteoarthritis; Systemic scleroderma
  • Phase II Amyotrophic lateral sclerosis; Dermatomyositis; Familial Mediterranean fever; Polymyalgia rheumatica; Polymyositis; Pulmonary arterial hypertension; Schnitzler syndrome
  • No development reported Chronic lymphocytic leukaemia
  • Discontinued Ankylosing spondylitis; Crohn's disease; Multiple myeloma; Pancreatic cancer; Systemic lupus erythematosus

Most Recent Events

  • 13 Sep 2018 Registered for Juvenile rheumatoid arthritis (active systemic juvenile idiopathic arthritis (sJIA), (Combination therapy) in USA (SC)
  • 13 Aug 2018 University of Nebraska and Genentech withdraws a phase II trial in Diabetic macular oedema in USA prior to enrolment (NCT02511067)
  • 11 Jul 2018 Barrow Neurological Institute and Genentech completes a phase II trial in Amyotrophic lateral sclerosis in USA (IV) (NCT02469896)
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