Tocilizumab - Roche

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Drug Profile

Tocilizumab - Roche

Alternative Names: Actemra; Anti-IL-6 receptor antibody - Chugai; Anti-interleukin-6 receptor antibody - Chugai; Atlizumab; HPM-1; MRA; MRA - Chugai; MRA-SC; R-1569; RG-1569; rhPM-1; RO4877533; RoActemra

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Chugai Pharmaceutical; Osaka University
  • Developer Assistance Publique Hopitaux de Paris; Charite - Universitatsmedizin Berlin; Chugai Pharmaceutical; Hospital for Special Surgery; JW Pharmaceutical; Roche; University Hospital Inselspital; University of Bern; University of Pittsburgh
  • Class Antirheumatics; Monoclonal antibodies
  • Mechanism of Action Immunosuppressants; Interleukin 6 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Giant lymph node hyperplasia; Vasculitis; Drug hypersensitivity; Systemic scleroderma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Giant lymph node hyperplasia; Juvenile rheumatoid arthritis; Rheumatoid arthritis
  • Registered Drug hypersensitivity; Giant cell arteritis; Vasculitis
  • Phase III Osteoarthritis; Systemic scleroderma
  • Phase II Amyotrophic lateral sclerosis; Dermatomyositis; Polymyalgia rheumatica; Polymyositis; Schnitzler syndrome
  • Phase I Chronic lymphocytic leukaemia
  • Discontinued Ankylosing spondylitis; Crohn's disease; Multiple myeloma; Pancreatic cancer; Systemic lupus erythematosus

Most Recent Events

  • 16 Feb 2018 Roche terminates a phase III extension trial in Rheumatoid arthritis in Poland due due to market authorisation of tocilizumab for the study population (NCT01665430)
  • 01 Jan 2018 Chugai Pharmaceutical completes the phase III TAKT trial in Vasculitis (Takayasu arteritis, In adolescents, In adults, In children, In the elderly) in Japan (SC) (JapicCTI-142616)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Juvenile-rheumatoid-arthritis in Germany (SC, Injection)
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