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Pegloticase - Horizon Therapeutics

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Drug Profile

Pegloticase - Horizon Therapeutics

Alternative Names: KRYSTEXXA; Methoxypolyethylene glycol uricase; PEG urate oxidase; PEG-uricase; PEGylated uricase; Polyethylene glycol-uricase; Puricase; Urate-oxidase-PEG

Latest Information Update: 28 Dec 2023

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At a glance

  • Originator Duke University; Mountain View Pharmaceuticals
  • Developer Horizon Pharma Rheumatology; Savient Pharmaceuticals
  • Class Antigouts; Oxidoreductases; Polyethylene glycols; Recombinant proteins
  • Mechanism of Action Urate oxidase replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gout
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Gout

Most Recent Events

  • 10 Nov 2023 Updated efficacy data from the phase IV MIRROR RCT trial in Gout presented at ACR Convergence 2023 (ACR-2023)
  • 31 May 2023 Updated efficacy data from the phase IV MIRROR RCT trial in Gout released by Horizon Therapeutics
  • 14 Nov 2022 Efficacy data from the phase IV MIRROR OL trial in Gout presented at the American College of Rheumatology Convergence 2022 (ACR-2022)

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